期刊
RNA BIOLOGY
卷 17, 期 8, 页码 1214-1222出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15476286.2020.1732694
关键词
tRNA fragments; RNA modifications; RNA epitranscriptomics; translation control; stem cells; development; hematopoiesis; pseudouridine; 5-methylcytosine
资金
- Cancerfonden [190321US, 190320PJ]
- Familjen Erling-Perssons Stiftelse [2017-2022]
- Ragnar Soderbergs stiftelse [2015-2020]
- Vetenskapsradet [2019-00982]
- Swedish Research Council [2019-00982] Funding Source: Swedish Research Council
- Vinnova [2019-00982] Funding Source: Vinnova
ABTRACT tRNA-derived fragments or tRFs were long considered merely degradation intermediates of full-length tRNAs; however, emerging research is highlighting unanticipated new and highly distinct functions in epigenetic control, metabolism, immune activity and stem cell fate commitment. Importantly, recent studies suggest that RNA epitranscriptomic modifications may provide an additional regulatory layer that dynamically directs tRF activity in stem and cancer cells. In this review, we explore current work illustrating unanticipated roles of tRFs in mammalian stem cells with a focus on the impact of post-transcriptional RNA modifications for the biogenesis and function of this growing class of small noncoding RNAs.
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