期刊
RNA BIOLOGY
卷 17, 期 11, 页码 1560-1575出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15476286.2020.1722449
关键词
RNA modifications; epitranscriptome; cancer
资金
- American Cancer Society [RSG-16-215-01-TBE, RSG-18-04301-LIB]
- National Institutes of Health [R01GM112003, R01HL134780, R01HL146852]
- National Science Foundation [1845486]
- Welch Foundation [BE-1913-20190330]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1845486] Funding Source: National Science Foundation
RNA plays essential roles in not only translating nucleic acids into proteins, but also in gene regulation, environmental interactions and many human diseases. Nature uses over 150 chemical modifications to decorate RNA and diversify its functions. With the fast-growing RNA research in the burgeoning field of 'epitranscriptome', a term describes post-transcriptional RNA modifications that can dynamically change the transcriptome, it becomes clear that these modifications participate in modulating gene expression and controlling the cell fate, thereby igniting the new interests in RNA-based drug discovery. The dynamics of these RNA chemical modifications is orchestrated by coordinated actions of an array of writer, reader and eraser proteins. Deregulated expression of these RNA modifying proteins can lead to many human diseases including cancer. In this review, we highlight several critical modifications, namely m(6)A, m(1)A, m(5)C, inosine and pseudouridine, in both coding and non-coding RNAs. In parallel, we present a few other cancer-related tRNA and rRNA modifications. We further discuss their roles in cancer promotion or tumour suppression. Understanding the molecular mechanisms underlying the biogenesis and turnover of these RNA modifications will be of great significance in the design and development of novel anticancer drugs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据