期刊
RETROVIROLOGY
卷 16, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12977-019-0503-0
关键词
HTLV-1; STLV-1; ATL; Prevalence; Interspecies transmission; Animal model; Therapy
类别
资金
- French Laboratory of Excellence project ECOFECT [ANR11-LABX-0048]
- Fondation pour la recherche medicale [DEQ20180339200]
- Labex Ecofect
- Ecole Normale Superieure de Lyon
- INSERM
Few years after HTLV-1 identification and isolation in humans, STLV-1, its simian counterpart, was discovered. It then became clear that STLV-1 is present almost in all simian species. Subsequent molecular epidemiology studies demonstrated that, apart from HTLV-1 subtype A, all human subtypes have a simian homolog. As HTLV-1, STLV-1 is the etiological agent of ATL, while no case of TSP/HAM has been described. Given its similarities with HTLV-1, STLV-1 represents a unique tool used for performing clinical studies, vaccine studies as well as basic science.
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