期刊
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
卷 40, 期 11, 页码 2184-2190出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/IAE.0000000000002721
关键词
diabetic macular ischemia; microperimetry; optical coherence tomography angiography; retinal sensitivity
资金
- SNEC Health Research Endowment Fund [R1433/16/2017]
Purpose: To examine the relationship between macular microvasculature parameters and functional changes in persons with diabetic retinopathy (DR). Methods: Cross-sectional study of 76 eyes with varying levels of DR. Optical coherence tomography angiography (OCTA) quantified superficial and deep perifoveal vessel densities and foveal avascular zone areas. Retinal sensitivity was measured using microperimetry. Optical coherence tomography angiography parameters and retinal sensitivity were correlated. Results: Deep perifoveal vessel density decreased with increasing severity of DR (adjusted mean 51.93 vs. 49.89 vs. 47.96, P-trend = 0.005). Superficial and deep foveal avascular zone area increased with increasing DR severity (adjusted mean: 235.0 mu m(2) vs. 303.4 mu m(2) vs. 400.9 mu m(2), P-trend = 0.003 [superficial]; 333.1 mu m(2) vs. 513.3 mu m(2) vs. 530.2 mu m(2), P-trend = 0.001 [deep]). Retinal sensitivity decreased with increasing DR severity (adjusted mean: 25.12 dB vs. 22.34 dB vs. 20.67 dB, P-trend = 0.003). Retinal sensitivity correlated positively with deep perifoveal vessel density (Pearson's rho = 0.276, P = 0.020) and inversely with superficial foveal avascular zone area (Pearson's rho = -0.333, P = 0.010). Conclusion: Alterations in retinal microvasculature can be observed with OCTA with increasing severity of DR. These changes are correlated with reduced retinal sensitivity. Optical coherence tomography angiography is useful to detect and quantify the microvasculature properties of eyes with diabetic macular ischemia.
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