期刊
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
卷 271, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.resp.2019.103310
关键词
Arterial chemoreceptor reflex; Breathing control; Brainstem; Nucleus of the solitary tract; Relaxin-3
资金
- Australian Research Council (ARC) [DP170104861]
- NHMRC (Australia) [1023321, 1023078]
- Victorian State Government Infrastructure Program
The neuropeptide relaxin-3 is expressed by the pontine nucleus incertus. Relaxin-3 and synthetic agonist peptides modulate arousal and cognitive processes via activation of the relaxin-family peptide 3 receptor (RXFP3). Despite the presence of RXFP3 in the nucleus of the solitary tract (NTS), the ability of RXFP3 to modulate NTS-mediated cardiorespiratory functions has not been explored. Therefore, we examined the effects of bilateral microinjections of the selective agonist, RXFP3-A2 (40 mu M, 100 nL/side), into the NTS in perfused working-heart-brainstem-preparations from rats (n = 6), while recording phrenic, vagal, and thoracic sympathetic chain activity (PNA, VNA, t-SCA) and heart rate (HR). RXFP3-A2 significantly increased respiratory rate and shortened post-inspiratory VNA. RXFP3-A2 in the NTS also significantly enhanced arterial chemoreceptor reflex (a-CR)-mediated tachypnea. However, RXFP3-A2 had no significant effect on HR and t-SCA at baseline or during the a-CR. These data represent the first evidence that RXFP3 activation in the NTS can selectively modulate respiration at baseline and during reflex behaviour.
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