期刊
REPRODUCTIVE TOXICOLOGY
卷 91, 期 -, 页码 109-115出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2019.11.009
关键词
Maternal micronutrient supplements; Autism spectrum disorder; Symptoms
资金
- National Natural Science Foundation of China [81771223, 81770526]
- Key Scientific and Technological Projects of Guangdong Province [2018B030335001]
- Key Laboratory of Family Planning Drugs, National Health Commission, 2018 annual open project [KF2018-3]
To explore possible associations between maternal use of micronutrient supplements and the subsequent vitamin levels and symptoms in offspring with autism spectrum disorder (ASD), a total of 416 children with ASD and 201 typically developing (TD) children were enrolled. The children born to mothers without folic acid (FA) and micronutrient supplementation during pregnancy had more severe social cognition impairments, social communication impairments, autism behaviour mannerisms, developmental delays in adaptive and gross motor behaviour and gastrointestinal problems than children born to mothers who used FA and micronutrient supplements (P < 0.05). Interestingly, there was an association between maternal micronutrient supplementation and vitamin A (VA), vitamin D (VD) and folate levels in the ASD children (P < 0.05), and levels of these vitamins also were associated with symptoms of ASD. Maternal FA and/or micronutrient supplementation may potentially moderate the symptoms of ASD. Interrupting the chain of micronutrient deficiencies between pregnant mothers and children may be beneficial in improving symptoms of ASD.
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