期刊
PSYCHOLOGICAL MEDICINE
卷 51, 期 7, 页码 1211-1219出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0033291719004124
关键词
cognitive bias modification; depression; emotion recognition; facial expression; interpretative bias; low mood
资金
- British Heart Foundation
- Cancer Research UK
- Economic and Social Research Council
- Medical Research Council
- National Institute for Health Research, under the UK Clinical Research Collaboration
- Medical Research Council [MR/J011819/1]
- NIHR Biomedical Research Centre at University Hospitals Bristol NHS Foundation Trust and the University of Bristol
- MRC [MR/N008103/1, MR/J011819/1] Funding Source: UKRI
This study investigated the effects of emotion recognition CBM on neural activity and depressive symptoms through two double blind RCTs, revealing that CBM can induce changes in emotion recognition bias but has limited impact on improving depressive symptoms.
Background There is demand for new, effective and scalable treatments for depression, and development of new forms of cognitive bias modification (CBM) of negative emotional processing biases has been suggested as possible interventions to meet this need. Methods We report two double blind RCTs, in which volunteers with high levels of depressive symptoms (Beck Depression Inventory ii (BDI-ii) > 14) completed a brief course of emotion recognition training (a novel form of CBM using faces) or sham training. In Study 1 (N = 36), participants completed a post-training emotion recognition task whilst undergoing functional magnetic resonance imaging to investigate neural correlates of CBM. In Study 2 (N = 190), measures of mood were assessed post-training, and at 2-week and 6-week follow-up. Results In both studies, CBM resulted in an initial change in emotion recognition bias, which (in Study 2) persisted for 6 weeks after the end of training. In Study 1, CBM resulted in increases neural activation to happy faces, with this effect driven by an increase in neural activity in the medial prefrontal cortex and bilateral amygdala. In Study 2, CBM did not lead to a reduction in depressive symptoms on the BDI-ii, or on related measures of mood, motivation and persistence, or depressive interpretation bias at either 2 or 6-week follow-ups. Conclusions CBM of emotion recognition has effects on neural activity that are similar in some respects to those induced by Selective Serotonin Reuptake Inhibitors (SSRI) administration (Study 1), but we find no evidence that this had any later effect on self-reported mood in an analogue sample of non-clinical volunteers with low mood (Study 2).
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