期刊
PROCESS BIOCHEMISTRY
卷 92, 期 -, 页码 303-312出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.procbio.2020.01.023
关键词
Pyrroloquinoline quinone; Alcoholic liver injury; Oxidative stress; Nrf2 signal pathway; NF-kappa B signal pathway
资金
- Natural Science Foundation for Young Scholars of Zhejiang Province [LQ20D060005]
- Natural Science Foundation of Zhejiang Province [LGC19C200004]
- National Natural Science Foundation of China [41806153]
The present study was aimed at investigating the hepatoprotective effect of pyrroloquinoline quinone (PQQ) against acute alcoholic liver injury in mice. Acute alcoholic liver injury model was established in mice, and they were administrated with PQQ to investigate its hepatoprotective effect. Our results shows that PQQ can significantly ameliorate acute alcoholic liver injury by decreasing the hepatic marker enzymes, including serum alanine transaminase (ALT) and aspartate transaminase (AST), and increasing the levels of alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) in the liver. And PQQ can also significantly reduce the content of hepatic triglyceride (TG) and malondialdehyde (MDA). Moreover, PQQ attenuated alcohol-induced oxidative damage by activating NF-E2-related factor 2 (Nrf2)-mediated signaling pathway, and inhibiting Toll-like receptor 4 (TLR4)-mediated nuclear factor-kappa B (NF-kappa B) signaling pathway. Our findings have elucidated the liver protection mechanism of PQQ, which would encourage the further exploitation of PQQ as a hepatoprotective functional food.
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