期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 117, 期 11, 页码 5949-5954出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1906954117
关键词
avian influenza; poultry trade; phylogeography; community-structured transmission
资金
- Beijing Natural Science Foundation [JQ18025]
- Beijing Advanced Innovation Program for Land Surface Science
- National Natural Science Foundation of China [81673234, 31822055]
- Shenzhen Science and Technology Research and Development Project [JCYJ20180504165549581]
- VIROGENESIS (Virus Discovery and Epidemic Tracing from High-Throughput Metagenomic Sequencing) from the European Union's Horizon 2020 research and innovation programme [634650]
- UK Global Challenges Research Fund (GCRF) One Health Poultry Hub
- National Key Research and Development Program of China [2016YFA0600104]
- Young Elite Scientist Sponsorship Program (YESS) by China Association for Science and Technology (CAST) [2018QNRC001]
- European Union Horizon 2020 research and innovation programme [725422-ReservoirDOCS]
- National Institutes of Health [U19 AI135995]
- Youth Innovation Promotion Association of the Chinese Academy of Sciences [2017122]
- Oxford Martin School
- Research Foundation-Flanders (Fonds voor Wetenschappelijk Onderzoek-Vlaanderen) [G066215N, G0D5117N, G0B9317N]
- Military Logistics Research Program
- BBSRC [BB/S011269/1] Funding Source: UKRI
The live poultry trade is thought to play an important role in the spread and maintenance of highly pathogenic avian influenza A viruses (HP AIVs) in Asia. Despite an abundance of small-scale observational studies, the role of the poultry trade in disseminating AIV over large geographic areas is still unclear, especially for developing countries with complex poultry production systems. Here we combine virus genomes and reconstructed poultry transportation data to measure and compare the spatial spread in China of three key subtypes of AIV: H5N1, H7N9, and H5N6. Although it is difficult to disentangle the contribution of confounding factors, such as bird migration and spatial distance, we find evidence that the dissemination of these subtypes among domestic poultry is geographically continuous and likely associated with the intensity of the live poultry trade in China. Using two independent data sources and network analysis methods, we report a regional-scale community structure in China that might explain the spread of AIV subtypes in the country. The identification of this structure has the potential to inform more targeted strategies for the prevention and control of AIV in China.
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