期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 116, 期 52, 页码 26280-26287出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1902292116
关键词
vision; retinal diseases; vision restoration; nonhuman primate; macaque
资金
- Programme Investissements d'Avenir IHU FOReSIGHT [ANR-18-IAHU-01]
- Programme Investissements d'Avenir LabEx LIFESENSES [ANR-10-LABX-65]
- European Research Council (ERC) Synergy HELMHOLTZ
- Banque publique d'Investissement
- Foundation Fighting Blindness
- ERC StG (REGENETHER) [639888]
- European Research Council (ERC) [639888] Funding Source: European Research Council (ERC)
Retinal degenerative diseases caused by photoreceptor cell death are major causes of irreversible vision loss. As only primates have a macula, the nonhuman primate (NHP) models have a crucial role not only in revealing biological mechanisms underlying high-acuity vision but also in the development of therapies. Successful translation of basic research findings into clinical trials and, moreover, approval of the first therapies for blinding inherited and age-related retinal dystrophies has been reported in recent years. This article explores the value of the NHP models in understanding human vision and reviews their contribution to the development of innovative therapeutic strategies to save and restore vision.
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