期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 117, 期 6, 页码 3248-3253出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1906144117
关键词
neurodevelopment; connectome; MRI; Allen Human Brain Atlas j; head movement
资金
- Neuroscience in Psychiatry Network Wellcome Trust [095844/Z/11/Z]
- (University College London)
- National Institute for Health Research (NIHR) Cambridge Biomedical Research Center
- Gates Cambridge Trust
- NIHR Biomedical Research Centre at South London and Maudsley National Health Service (NHS) Foundation Trust
- King's College London - Engineering and Physical Sciences Research Council (EPSRC) [EP/N510129/1, NF-SI-0514-10157]
- NIHR Collaboration for Leadership in Applied Health Research and Care North Thames at Barts Health NHS Trust
- Medical Research Council (MRC) [MR/K020706/1, MQF17/24]
- EPSRC [EP/N510129/1] Funding Source: UKRI
- MRC [MC_G0802534, MR/K020706/1] Funding Source: UKRI
Adolescent changes in human brain function are not entirely understood. Here, we used multiecho functional MRI (fMRI) to measure developmental change in functional connectivity (FC) of resting-state oscillations between pairs of 330 cortical regions and 16 subcortical regions in 298 healthy adolescents scanned 520 times. Participants were aged 14 to 26 y and were scanned on 1 to 3 occasions at least 6 mo apart. We found 2 distinct modes of age-related change in FC: conservative and disruptive. Conservative development was characteristic of primary cortex, which was strongly connected at 14 y and became even more connected in the period from 14 to 26 y. Disruptive development was characteristic of association cortex and subcortical regions, where connectivity was remodeled: connections that were weak at 14 y became stronger during adolescence, and connections that were strong at 14 y became weaker. These modes of development were quantified using the maturational index (MI), estimated as Spearman's correlation between edgewise baseline FC (at 14 y, FC14) and adolescent change in FC (Delta FC14-26), at each region. Disruptive systems (with negative MI) were activated by social cognition and autobiographical memory tasks in prior fMRI data and significantly colocated with prior maps of aerobic glycolysis (AG), AG-related gene expression, postnatal cortical surface expansion, and adolescent shrinkage of cortical thickness. The presence of these 2 modes of development was robust to numerous sensitivity analyses. We conclude that human brain organization is disrupted during adolescence by remodeling of FC between association cortical and subcortical areas.
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