期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 116, 期 52, 页码 26329-26331出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1913227117
关键词
auditory cortex; plasticity; GABA; parvalbumin; perineuronal nets
资金
- Canadian Institutes of Health Research (CIHR) [MOP-133426]
- CIHR Vanier Canada Graduate Scholarship
- Fonds de Recherche du Quebec-Societe et Culture
- Fonds de Recherche du Quebec-Nature et Technologies
Sensory experience during early developmental critical periods (CPs) has profound and long-lasting effects on cortical sensory processing perduring well into adulthood. Although recent evidence has shown that reducing cortical inhibition during adulthood reinstates CP plasticity, the precise cellular mechanisms are not well understood. Here, we show that chemogenetic inactivation of parvalbumin-positive (PV+) interneurons is sufficient to reinstate CP plasticity in the adult auditory cortex. Bidirectional manipulation of PV+ cell activity affected neuronal spectral and sound intensity selectivity and, in the case of PV+ interneuron inactivation, was mirrored by anatomical changes in PV and associated perineuronal net expression. These findings underscore the importance of sustained PV-mediated inhibitory neurotransmission throughout life and highlight the potential of chemogenetic approaches for harnessing cortical plasticity with the ultimate goal of aiding recovery from brain injury or disease.
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