One-pot three-component synthesis of propargylamines using an efficient and reusable copper bio-functionalized magnetic graphene oxide nanocomposite

In this work, magnetic graphene oxide was produced through chemical oxidation of the graphite powder, exfoliation under ultrasonic waves and then magnetization in the presence of ion salts. Magnetic graphene oxide was functionalized with cysteine and used as efficient support for the immobilization and suitable dispersing of copper ions. This nanocatalyst was characterized using FT-IR, TEM, EDX, XRD, VSM, XPS and ICP-OES analysis. Very low loading of prepared nanocomposite was showed high activity in the synthesis of propargylamine derivatives via A(3)-coupling reaction. It simply recovered from the reaction mixture by using an external magnetic field and reused without any pre-activation in next tests with acceptable yields. (C) 2019 Elsevier Ltd. All rights reserved.