A Versatile Protocol for Synthesis of 2H-Indazolo[2,1-b]Phthalazine Triones Using γ-Al2O3/BFn/Fe3O4 as an Efficient Magnetic Nano-Catalyst

A four-component reaction of aromatic aldehydes, phthalic anhydride, hydrazine monohydrate and dimedone has been achieved in the presence of nano-gamma-Al2O3/BFn/Fe3O4 as a highly effective heterogeneous catalyst to produce 2H-indazolo[2,1-b]phthalazine triones. Atom economy, low catalyst loading, reusable catalyst, applicability to a wide range of substrates and high yields of products are some important features of this protocol.

Automated summary

A four-component reaction of aromatic aldehydes, phthalic anhydride, hydrazine monohydrate and dimedone has been achieved in the presence of nano-gamma-Al2O3/BFn/Fe3O4 as a highly effective heterogeneous catalyst to produce 2H-indazolo[2,1-b]phthalazine triones. Atom economy, low catalyst loading, reusable catalyst, applicability to a wide range of substrates and high yields of products are some important features of this protocol.