Development of Glucose Sensor Using Gold Nanoparticles and Glucose-Oxidase Functionalized Tapered Fiber Structure

Diabetes mellitus is a common health issue in human beings. It is very important to develop a highly selective and sensitive biosensor for the detection of glucose concentration in the human body. The proposed sensor is based on localized surface plasmon resonance (LSPR) technique. An optical tapered fiber structure is used to develop the proposed sensor. Gold nanoparticles (AuNPs) are used to increase the sensitivity of the sensor probe. AuNPs of size similar to 10 nm is synthesized for this purpose. The characterization of AuNPs was performed with the UV-vis spectroscopy, transmission electron microscope (TEM), and scanning electron microscope (SEM). Further, glucose oxidase enzyme is used to increase the selectivity of the sensor. The selectivity of sensor is tested with different analytes such as cholesterol, urea, L-cysteine, ascorbic acid, and galactose that are generally found in the serum.