期刊
PLACENTA
卷 93, 期 -, 页码 113-118出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.placenta.2020.03.004
关键词
Placenta; Fetal growth restriction (FGR); Magnetic resonance imaging (MRI); Diffusion weighted imaging (DWI); Intra-voxel incoherent motion analysis (IVIM)
资金
- National Institutes of Health [R01-HL116585, 1U54HD090257, UL1TR000075, KL2TR000076, 1K23HD09258501A1]
Introduction: Gross and microstructural changes in placental development can influence placental function and adversely impact fetal growth and well-being; however, there is a paucity of invivo tools available to reliably interrogate in vivo placental microstructural development. The objective of this study is to characterize invivo placental microstructural diffusion and perfusion in healthy and growth-restricted pregnancies (FGR) using noninvasive diffusion-weighted imaging (DWI). Methods: We prospectively enrolled healthy pregnant women and women whose pregnancies were complicated by FGR. Each woman underwent DWI-MRI between 18 and 40 weeks gestation. Placental measures of small (D) and large (D*) scale diffusion and perfusion (f) were estimated using the intra-voxel incoherent motion (IVIM) model. Results: We studied 137 pregnant women (101 healthy; 36 FGR). D and D* are increased in late-onset FGR, and the placental perfusion fraction, f, is decreased (p < 0.05 for all). Discussion: Placental DWI revealed microstructural alterations of the invivo placenta in FGR, particularly in lateonset FGR. Early and reliable identification of placental pathology in vivo may better guide future interventions.
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