期刊
PHYTOTHERAPY RESEARCH
卷 34, 期 6, 页码 1329-1337出版社
WILEY
DOI: 10.1002/ptr.6599
关键词
erythropoietin; flavonoid; hypoxia response element; hypoxia-inducible factor; tectorigenin
资金
- Hong Kong Innovation Technology Fund [HMRF18SC06, ITS/500022/18FP, TCPD/17-9, UIM/340, UIM/385, ITS/500/18FP]
- Hong Kong RGC Theme-based Research Scheme [T13-607/12R]
- Guangzhou Science and Technology Committee Research Grant [GZSTI16SC02, GZSTI17SC02]
- Shenzhen Science and Technology Innovation Committee [CKFW2016 082916015476, JCYJ20160229205812004, JCYJ20160229210027564, JCYJ20170413173747440, JCYJ20180214151016621, JCYJ20180306174903174, ZDSYS201707281432317]
Traditional Chinese medicines (TCMs) have been demonstrated as an important source for potential drug discovery. Flavonoids are regarded as the most common active components in TCMs because of their beneficial functions in the brain and erythropoietic system. Erythropoietin (EPO), a glycoprotein hormone, has been well-studied for its neuroprotective function. The blood circulating EPO is not able to cross the blood brain barrier, and thus there is mounting demand to search for compounds that can induce endogenous cerebral EPO. Here, tectorigenin, an active compound in the rhizome of Belamcanda chinensis (L.) DC., significantly induced the expression of EPO mRNA via accumulation of hypoxia-inducible factor (HIF)-1 alpha in cultured neuron-like NT2/D1 cells and rat cortical neurons. Furthermore, tectorigenin induced transcription of HIF-1 alpha and reduced degradation of HIF-1 alpha-OH, a hydroxylated form of HIF-1 alpha, in the culture. Thus, the upregulation of HIF-1 alpha was assumed to play a significant role in regulating EPO during the treatment of tectorigenin in cultured neurons. Hence, we reported the neuroprotective function of tectorigenin through upregulation of EPO in neurons, which could be a good candidate in developing drugs or food supplements for the treatment of brain disorders.
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