期刊
PHYTOCHEMISTRY LETTERS
卷 34, 期 -, 页码 30-34出版社
ELSEVIER
DOI: 10.1016/j.phytol.2019.09.004
关键词
Ascidian-derived fungus; Aspergillus clavatus; Secondary metabolites; Antibacterial activity
资金
- NSFC-Shandong Joint Fund for Marine Science Research Centers [U1606403]
- Taishan Scholar Project from Shandong Province of China
Six secondary metabolites including a new aminobenzoic peptide seco-clavatustide B (1) and a new clavatoic acid derivative 5-acetyl-2,4-dihydroxy-3-methylbenzoic acid (3), were characterized from the EtOAc extracts of the Ascidian-derived endophytic fungus Aspergillus clavatus AS-107. The absolute configuration of compound 1 was established by electronic circular dichroism quantum calculation and the structure of compound 3 was elucidated on the basis of spectroscopic data together with single-crystal X-ray diffraction experiment. The isolated compounds were tested for antimicrobial activities against human and aquatic pathogenic bacteria. Compounds 1 and 2 showed potent activity against aquatic pathogens Aeromonas hydrophilia and Pseudomonas aeruginosa with MIC values of 8.2 and 8.8 mu M, respectively.
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