期刊
PHYTOCHEMISTRY LETTERS
卷 34, 期 -, 页码 18-24出版社
ELSEVIER
DOI: 10.1016/j.phytol.2019.09.002
关键词
Marine-derived fungus; Penicillium ubiquetum; C25 steroids; HRMS/MS dereplication
资金
- Vietnam International Education Development program
Two new unusual C25 steroid epimers, 24-O-methyl-24-epi-cyclocitrinol (1) and 24-O-methylcyclocitrinol (2), together with the known oxylipin alpha-dimorphecolic acid (3), were isolated from the extract of cultures of a Penicillium ubiquetum MMS330 strain sampled from the blue mussel Mytilus edulis. The structures of the new compounds were established based on 1D and 2D NMR spectral analyses and CP3 conformation analysis. LC-MS dereplication of other C25 steroids in culture extracts was also performed on the basis of their HRMS/MS fragmentation patterns, allowing to detect other analogues. Biological activities of compounds 1 and 2 were evaluated as a mixture on the two human cancer cell lines KB and MCF-7.
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