Three new 3,8-epoxy iridoids from the roots and rhizomes of Valeriana jatamansi

Three new 3,8-epoxy iridoids, jatamanins V-X (1-3), and three known ones (4-6), were obtained from the roots and rhizomes of Valeriana jatamansi. The structures of 1-3 were determined through their NMR and high-resolution mass spectroscopic analysis. Among them, compounds 1 and 2 were a pair of C-4 diastereomers. Additionally, all compounds were evaluated for their cytotoxic effects against glioma stem cells.