期刊
PHYTOCHEMISTRY
卷 170, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2019.112192
关键词
Eclipta prostrata; Compositae; Terpenoid; alpha-glucosidase; Cytotoxicity; Antibacterial
资金
- Natural Science Foundation of Shandong Province [JQ201721]
- Young Taishan Scholars Program [tsqn20161037]
- Innovation Team Project of Jinan Science & Technology Bureau [2018GXRC003]
- Shandong Talents Team Cultivation Plan of University Preponderant Discipline [10027]
Chemical fractionation of the ethanolic extract of Eclipta prostrata yielded a series of unreported terpenoid constituents, including a rare 6/6/6/6-fused tetracyclic triterpenoid, a pentacyclic triterpenoid, two pentacyclic triterpenoid saponins, a diterpenoid and a sesquiterpenoid. Structures were assigned to these compounds on the basis of comprehensive spectroscopic analyses, with the absolute configurations of the tetracyclic triterpenoid, the diterpenoid and the sesquiterpenoid being determined via explanation of electronic circular dichroism data. Screening of these isolates in an array of bioassays revealed antibacterial, cytotoxic and alpha-glucosidase inhibitory activities for selective compounds. Of particular interest, the tetracyclic triterpenoid showed very strong inhibition against alpha-glucosidase with an IC50 of 0.82 +/- 0.18 mu M, being 10(3)-fold as active as the positive control acarbose.
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