期刊
PHYSIOLOGY
卷 35, 期 2, 页码 86-95出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiol.00034.2019
关键词
Warburg effect; oxidative phosphorylation; lactate metabolism; pyruvate dehydrogenase kinase; pyruvate dehydrogenase complex; oxidative stress; free radicals; reactive oxygen species
类别
In cancer cells, glucose is primarily metabolized to pyruvate and then to lactate in the cytosol. By allowing the conversion of pyruvate to acetyl-CoA in mitochondria, melatonin reprograms glucose metabolism in cancer cells to a normal cell phenotype. Acetyl-CoA in the mitochondria also serves as a necessary co-factor for the rate-limiting enzyme in melatonin synthesis, thus ensuring melatonin production in mitochondria of normal cells.
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