期刊
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
卷 195, 期 4, 页码 339-347出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10426507.2019.1700258
关键词
alpha-Aminophosphonates; copper(II) complexes; spectroscopic characterization; anticancer activity
A one pot procedure was used to synthesize two new derivatives of alpha-aminophosphonates. Novel copper(II) complexes of alpha-aminophosphonates were synthesized by coordinating different copper salts with the newly synthesized alpha-aminophosphonates. Their structures were characterized by different spectral and analytical techniques. Evaluation of the metal-free ligands HL1, HL2, and their Cu(II) complexes against human colon carcinoma HT-29 cell lines was performed, using cisplatin as a reference drug. The results indicated that the complexes of the ligand HL1 exhibited enhanced anticancer activity, while ligand HL2 complexes showed decreased anticancer activity.
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