期刊
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
卷 375, 期 1795, 页码 -出版社
ROYAL SOC
DOI: 10.1098/rstb.2019.0341
关键词
ATAC-seq; RNA-seq; cap-n-collar (cnc); adaptation; transcription factor-binding sites
类别
资金
- European Commission [H2020-ERC-2014-CoG-647900]
- Ministerio de Ciencia, Innovacion y Universidades/AEI/FEDER [BFU2017-82937-P]
- Secretaria d'Universitats i Recerca. Departament d'Economia i Coneixement. Generalitat de Catalunya [GRC 2017 SGR 880]
- Juan de la Cierva-Formacion fellowship [FJCI-2016-28380]
Most of the genotype-phenotype analyses to date have largely centred attention on single nucleotide polymorphisms. However, transposable element (TE) insertions have arisen as a plausible addition to the study of the genotypic-phenotypic link because of to their role in genome function and evolution. In this work, we investigate the contribution of TE insertions to the regulation of gene expression in response to insecticides. We exposed four Drosophila melanogaster strains to malathion, a commonly used organophosphate insecticide. By combining information from different approaches, including RNA-seq and ATAC-seq, we found that TEs can contribute to the regulation of gene expression under insecticide exposure by rewiring cis-regulatory networks. This article is part of a discussion meeting issue 'Crossroads between transposons and gene regulation'.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据