4.6 Article

Transposable elements contribute to the genomic response to insecticides in Drosophila melanogaster

出版社

ROYAL SOC
DOI: 10.1098/rstb.2019.0341

关键词

ATAC-seq; RNA-seq; cap-n-collar (cnc); adaptation; transcription factor-binding sites

类别

资金

  1. European Commission [H2020-ERC-2014-CoG-647900]
  2. Ministerio de Ciencia, Innovacion y Universidades/AEI/FEDER [BFU2017-82937-P]
  3. Secretaria d'Universitats i Recerca. Departament d'Economia i Coneixement. Generalitat de Catalunya [GRC 2017 SGR 880]
  4. Juan de la Cierva-Formacion fellowship [FJCI-2016-28380]

向作者/读者索取更多资源

Most of the genotype-phenotype analyses to date have largely centred attention on single nucleotide polymorphisms. However, transposable element (TE) insertions have arisen as a plausible addition to the study of the genotypic-phenotypic link because of to their role in genome function and evolution. In this work, we investigate the contribution of TE insertions to the regulation of gene expression in response to insecticides. We exposed four Drosophila melanogaster strains to malathion, a commonly used organophosphate insecticide. By combining information from different approaches, including RNA-seq and ATAC-seq, we found that TEs can contribute to the regulation of gene expression under insecticide exposure by rewiring cis-regulatory networks. This article is part of a discussion meeting issue 'Crossroads between transposons and gene regulation'.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据