期刊
PHARMACOLOGICAL RESEARCH
卷 151, 期 -, 页码 -出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phrs.2019.104537
关键词
Megalin; Kidney; Renin angiotensin system; Atherosclerosis
资金
- National Heart, Lung, and Blood Institute of the National Institutes of Health [R01HL133723, R01HL139748]
- American Heart Association SFRN in Vascular Disease [18SFRN33960001]
- American Heart Association [18POST33990468]
Megalin is a member of the low-density lipoprotein receptor superfamily. It has been recognized as an endocytic receptor for a large spectrum of ligands. As a consequence, megalin regulates homeostasis of many molecules and affects multiple physiological and pathophysiological functions. The renin-angiotensin system is a hormonal system. A number of studies have reported contributions of the renin-angiotensin system to atherosclerosis. There is evolving evidence that megalin is a regulator of the renin-angiotensin system, and contributes to atherosclerosis. This brief review provides contemporary insights into effects of megalin on renal functions, the renin-angiotensin system, and atherosclerosis.
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