期刊
PEDIATRIC INFECTIOUS DISEASE JOURNAL
卷 38, 期 12, 页码 1236-1241出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/INF.0000000000002492
关键词
early-onset sepsis; preterm; neonatal intensive care units; epidemiology; pathogens
资金
- China Medical Board [14-194]
- Key Developing Discipline of the Shanghai Municipal Health Commission (Pediatrics) [2016ZB0101]
- Canadian Institutes of Health Research [CTP 87518]
Background: The epidemiology of early-onset sepsis (EOS) in China is poorly understood because of the paucity of high-quality data. We aimed to examine the epidemiology, pathogen distribution and neonatal outcomes of EOS among a large cohort of preterm infants in China. Methods: All infants born at Results: Among 27,532 enrolled infants, 321 (11.7 cases per 1000 admissions) infants developed EOS, and 61 (19.0%) infants died within seven days after EOS onset. The incidence of EOS among inborn infants in 18 perinatal centers was 9.7 cases per 1000 live births <34 weeks' gestation (186/19,084). The case fatality rate was 22.6% (42/186). Gram-negative bacteria were responsible for 61.7% of EOS and 82.0% of EOS-related deaths. Escherichia coli (20.3%) was the leading pathogen, followed by Coagulase-negative staphylococcus (16.5%), Achromobacter xylosoxidans (9.0%) and Klebsiella pneumoniae (8.1%). Group B streptococci infections were relatively rare (2.5%). EOS was an independent risk factor for all-cause mortality and retinopathy of prematurity. Conclusions: There is a high burden of EOS among preterm infants in China with a distinctive pathogen distribution. Longitudinal epidemiologic monitoring, further investigation of causative pathogens and development of targeted strategies for prevention and treatment of EOS are needed.
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