期刊
PEDIATRIC BLOOD & CANCER
卷 67, 期 5, 页码 -出版社
WILEY
DOI: 10.1002/pbc.28187
关键词
children; cure; hematopoietic stem cell transplantation; Mendelian susceptibility to mycobacterial diseases
资金
- Pediatric Critical Care Group
We present our experience in the hematopoietic stem cell transplantation (HSCT) in two children diagnosed with Mendelian susceptibility to mycobacterial diseases. The first child underwent a haploidentical HSCT with posttransplant cyclophosphamide using a reduced intensity conditioning following which he had primary graft failure. He was subsequently found to have interferon-gamma 1 receptor deficiency. He had immune reconstitution and is on antitubercular therapy. The second child diagnosed with IL12RB1 gene mutation underwent matched sibling donor HSCT with myeloablative conditioning following pretransplant immunosuppression with fludarabine and dexamethasone. He is 13 months post-HSCT with complete and remains disease free.
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