期刊
PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
卷 37, 期 2, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ppsc.201900471
关键词
calcium carbonate nanoparticles; contrast enhanced ultrasound imaging; protein corona; red blood cell membranes
资金
- State Government of Victoria
- Australian Government
This work reports the fabrication of biocompatible and pH-sensitive hybrid polydopamine/bovine serum albumin/calcium carbonate (PDA/BSA/CaCO3) particles via a rapid precipitation method. These hybrid particles generate hyperechogenic carbon dioxide bubbles upon exposure to low pH environments, making them ideal as a contrast agent and detector for tumor cells. This study also highlights the application of red blood cell membrane (RBC)-derived membranes as a biomimetic coating for PDA/BSA/CaCO3 hybrid particles in order to modulate protein corona formation, a natural physiological response that alters tailored properties of most nanomaterials that are administered systemically. Results of this work demonstrate that the RBC membrane-coated hybrid particles are ideal for a wide range of biomedical applications, such as noninvasive multimodal imaging, photothermal and photodynamic therapy, and personalized drug delivery systems.
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