期刊
PAEDIATRIC RESPIRATORY REVIEWS
卷 36, 期 -, 页码 128-135出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.prrv.2020.01.002
关键词
Sleep; Sleep disordered breathing; Obstructive sleep apnoea; Phenotyping; Personalised medicine
资金
- Australian Government's Research Training Program Stipend
- Heart Foundation of Australia [101167]
The concept of personalised medicine is likely to revolutionise the treatment of adult obstructive sleep apnoea as a result of recent advances in the understanding of disease heterogeneity by identifying clinical phenotypes, pathophysiological endotypes, biomarkers and treatable traits. Children with the condition show a similar level of heterogeneity and paediatric obstructive sleep apnoea would also benefit from a more targeted approach to diagnosis and management. This review aims to summarise the adult literature on the phenotypes and endotypes of obstructive sleep apnoea and assess whether a similar approach may also be suitable to guide the development of new diagnostic and management approaches for paediatric obstructive sleep apnoea. (c) 2020 Elsevier Ltd. All rights reserved.
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