期刊
OSTEOARTHRITIS AND CARTILAGE
卷 28, 期 5, 页码 532-543出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.joca.2020.01.016
关键词
Osteoarthritis; Innate immunity; Cells; Effector molecules; Cytokines
Inflammatory changes are observed in affected joints of osteoarthritis (OA) patients and are thought to be involved in the pathology that develops along OA progression. This narrative review provides an overview of the various cell types that are present in the joint during OA and which alarmins, cytokines, chemokines, growth factors, and other mediators they produce. Moreover, the involvement of more systemic processes like inflammaging and its associated cellular senescence in the context of OA are discussed. (C) 2020 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
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