期刊
OSTEOARTHRITIS AND CARTILAGE
卷 28, 期 3, 页码 356-362出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.joca.2019.12.010
关键词
Anterior cruciate ligament injury; Biomarkers; Inflammation; Synovitis; Patient reported outcomes
资金
- Swedish Research Council
- Medical Faculty of Lund University
- Region Skane
- Governmental funding of clinical research within the national health services (ALF)
- Swedish Rheumatism Association
- Thelma Zoegas Fund
- Stig & Ragna Gorthon Research Foundation
- Swedish National Centre for Research in Sports
- Crafoord Foundation
- Tore Nilsson Research Fund
- Pfizer Global Research
Objective: To estimate the association between molecular or imaging inflammatory biomarkers at 2 years after anterior cruciate ligament (ACL) injury and patient-reported outcomes at 5 years. Methods: For 116 ACL-injured patients, molecular biomarkers of inflammation (synovial fluid and serum cytokines) and Hoffa- and effusion-synovitis as visualized on magnetic resonance imaging (MRI) were assessed 2 years post-injury. Knee injury and Osteoarthritis Outcome Score (KOOS) and SF-36 were assessed at 2 and 5 years. We used multiple imputation to handle biomarker values that were below the level of detection or missing, and linear regression for statistical analyses. Results: None of the synovial fluid cytokines or imaging biomarkers of inflammation at 2 years were associated with any of the patient-reported outcomes at 5 years. With each log10 unit higher of serum tumor necrosis factor concentration the knee-related quality of life of KOOS was increased (i.e., better outcome) by 35 (95% confidence interval 7 to 63) points. No other serum biomarker measured at 2 years was associated with patient-reported outcome at 5 years. Conclusion: Local joint inflammation assessed by biomarkers in synovial fluid and Hoffa- and effusion-synovitis on MRI at 2 years after an ACL injury did not associate with patient-reported outcomes at 5 years. Thus, chronic inflammation in the ACL-injured knee, as reflected by the biomarkers studied here, seems not to be a key determinant for the long-term patient-reported outcomes. (C) 2020 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
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