期刊
ORGANIC LETTERS
卷 22, 期 5, 页码 2022-2025出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c00399
关键词
-
资金
- National Science Foundation of China [21732001, 21871118, 21572088]
- PCSIRT [IRT_15R28]
The first total synthesis of Gardneria oxindole alkaloid (-)-gardmultimine A has been achieved in 19 steps from D-tryptophan in a fully stereocontrolled manner. This synthesis features (1) an Ir-catalyzed regioselective C-H borylation/oxidation sequence to introduce the C12 methoxyl group, (2) a stereocontrolled oxidative rearrangement of indole to construct the spirooxindole motif, and (3) an Au(I)-catalyzed transannular Conia-ene-type 6-exo-dig cyclization to establish the azabicyclo[2.2.2]-octane skeleton and the exocyclic E-alkene with exclusive stereoselectivity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据