期刊
ORGANIC LETTERS
卷 22, 期 5, 页码 1883-1888出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c00221
关键词
-
资金
- Koshiyama Research Grant
An efficient gold-catalyzed cyclization of 2-alkynylaldehyde cyclic acetals has been developed for the synthesis of indenone derivatives. A wide variety of functionalized indenone derivatives can be obtained in good-to-excellent yields. HMBC and NOESY NMR analyses and mechanistic elucidation experiments revealed that the cyclization occurs via a 1,5-H shift. The cyclic acetal group promoted the 1,5-H shift by activating the benzylic C-H bond and preventing the migration of the alkoxy group by tethering both alkoxy groups.
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