期刊
ORGANIC LETTERS
卷 22, 期 6, 页码 2437-2441出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c00646
关键词
-
资金
- Swiss National Science Foundation [P300P2-171434]
- Swiss National Science Foundation (SNF) [P300P2_171434] Funding Source: Swiss National Science Foundation (SNF)
Enantioselective incorporation of trifluoromethyl (-CF3) and trifuoromethylthio (-SCF3) groups in small molecules is of high interest to modulate the potency and pharmacological properties of drug candidates. Herein, we report a Zn-ProPhenol catalyzed diastereo- and enantioselective Mannich addition of alpha-trifluoromethyl- and alpha-trifuoromethylthio-substituted ketones. This transformation uses cyclic and acyclic ketones and generates quaternary trifluoromethyl and tetrasubstituted trifuoromethylthio stereogenic centers in excellent yields and selectivities.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据