期刊
ORGANIC LETTERS
卷 22, 期 3, 页码 832-836出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b04277
关键词
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资金
- Ministry of Science and Technology of China [2017YFA0206903]
- National Natural Science Foundation of China [21861132004]
- Strategic Priority Research Program of the Chinese Academy of Science [XDB17000000]
- Key Research Program of Frontier Sciences of the Chinese Academy of Science [QYZDY-SSW-JSCO29]
- K. C. Wong Education Foundation
A unified strategy for the synthesis of 2-vinyl heterocycles is reported. With visible light irradiation, simple and cheap CuCl is able to functionalize a terminal alkyne, giving Cu(I)-acetylide in situ. Unlike the case of noble metals or organic dye photocatalysts, this critical Cu(I)-acetylide not only activates the C-H bond of terminal alkynes but also serves as a photocatalyst to achieve varieties of 2-vinyl heterocycles in good to excellent yields, even for large scale and late-stage functionalization of natural product.
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