期刊
ORGANIC LETTERS
卷 22, 期 3, 页码 873-878出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b04398
关键词
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资金
- National Natural Science Foundation of China [U1504206]
- Program for Innovation Teams in Science and Technology in Universities of Henan Province [20IRTSTHNO04]
- Henan University [SYL19030204, SYL19060137]
New chalcone-based pyridinium salts have been successfully exploited, which could smoothly participate in the highly diastereoselective dearomatization with binucleophilic enaminones by taking advantage of their multiple reactive sites to construct bibridged benzoazepines in up to 89% yields. The key to the success was the skillful and unprecedented C-3 functionalization of the new pyridinium salts. This work not only provides a kind of novel pyridinium salt synthon but also achieves the first C-3 functionalization of pyridinium salts to construct complex and challenging bibridged benzoazepines with high synthetic efficiency.
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