期刊
ORGANIC LETTERS
卷 22, 期 3, 页码 804-808出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b04160
关键词
-
资金
- UCLA from Fuzionaire Diagnostics, Inc.
A new class of organosilicon-based radiosynthons, heteroaromatic silicon-fluoride acceptors, namely, HetSiFAs, that readily undergo isotope exchange with dry [F-18]fluoride at room temperature in high radiochemical yield (up to 94%) with good molar activity is reported. Radiofluorination proceeds in a single step in 2 min without high-performance liquid chromatography purification to provide an operationally simple method for F-18-PET tracer production. This method was used to prepare an F-18-labeled commercial tetrapeptide, and positron emission tomography imaging confirmed in vivo stability.
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