4.8 Article

CuSO4-Catalyzed Tandem C(sp3)-H Insertion Cyclization of Toluenes with Isonitriles to Form Indoles

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ORGANIC LETTERS
卷 22, 期 2, 页码 357-360

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AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b03751

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资金

  1. National Natural Science Foundation of China [21602001, 21922109, 21672196, 21831007]
  2. Fundamental Research Funds for the Central Universities of China [WK2060190086]

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A CuSO4-catalyzed tandem benzylic C-H insertion cyclization of toluene derivatives and isonitriles is described. The naturally abundant salt CuSO4 serves as a low-cost ligand-free redox catalyst. This reaction provides a practical modular synthesis of N-aryl indoles from isonitriles.

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