期刊
ORGANIC LETTERS
卷 22, 期 1, 页码 239-243出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b04199
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资金
- Chemistry Department of Universidad de los Andes (UniAndes)
- Faculty of Science
- Faculty of Science of UniAndes [INV-2018-48-1337]
- Fapesp [2017/24017-0]
A simple, inexpensive, step economic, and highly modular synthetic strategy to access izidine alkaloids is described. The key step is a TfOH-promoted intramolecular aldol condensation between enol and cyclic imide moieties. This cyclization strategy can be employed within an aza-Robinson annulation framework and represents a general tool to build fused bicyclic amines. To illustrate the power of this method, we describe the preparation of (+/-)-coniceine, (+/-)-quinolizidine, (+/-)-tashiromine, (+/-)-epilupinine, and the core of (+/-)-valmerins
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