期刊
ORGANIC LETTERS
卷 21, 期 24, 页码 10149-10153出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b04216
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-
资金
- Canadian Institute For Advanced Research
- Queen Elizabeth II Graduate Scholarship
Spin-labeled amino acids (SLAAs) are often used to determine intermolecular distances and conformations in proteins via double electron-electron resonance. Currently available SLAAs can be difficult to incorporate selectively and have little resemblance to natural side chains in proteins. Enantioselective synthesis of three spin-labeled L-amino acids is described, starting from readily available 2,2,6,6-tetramethyl-4-piperidinone. These SLAAs better replicate canonical residues in proteins and aim for biological incorporation via genetic incorporation or solid-phase peptide synthesis.
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