期刊
ORAL ONCOLOGY
卷 102, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.oraloncology.2019.104552
关键词
Oral cancer; Oral cavity cancer; Head and neck cancer; Squamous cell carcinoma; Head and neck squamous cell carcinoma; HNSCC; Cancer genetics; Molecular biology of oral cavity squamous cell carcinoma; Immunotherapy; Epigenetics
资金
- NIH Medical Scientist National Research Service Award [T32 GM007281]
- University of Chicago Comprehensive Cancer Center
Oral cavity squamous cell carcinoma (OCSCC) is a heterogeneous and complex disease that arises due to dysfunction of multiple molecular signaling pathways. Recent advances in high-throughput genetic sequencing technologies coupled with innovative analytical techniques have begun to characterize the molecular determinants driving OCSCC. An understanding of the key molecular signaling networks underlying the initiation and progression of is essential for informing treatment of the disease. In this chapter, we discuss recent findings of key genes altered in OCSCC and potential treatments targeting these genes.
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