期刊
ORAL DISEASES
卷 27, 期 1, 页码 21-26出版社
WILEY
DOI: 10.1111/odi.13308
关键词
early diagnosis; fluorescence imaging; fluorescence-guided surgery; molecular imaging; oral squamous cell carcinoma; surgical resection margin evaluation
Early diagnosis and aggressive surgical excision are crucial for optimal treatment outcomes in oral squamous cell carcinomas. However, current diagnostic tools and intraoperative assessment methods are limited, leading to late-stage detection of oral cancer.
Early diagnosis and radical surgical excision of oral squamous cell carcinomas are essential for achieving optimal treatment outcomes. To date, diagnostic tools that rely on anatomical anomalies provide limited information and resolution in clinical practice. As a result, oral cancer is often detected in an advanced stage. Also, no reliablereal-timeintraoperative tools are readily available for the evaluation of surgical resection margins. Fluorescence imaging visualises biological processes that occur in early carcinogenesis and could, therefore, enable detection of small tumours in early stages. Furthermore, due to the high sensitivity and spatial resolution, fluorescence imaging could assist in resection margin assessment during surgery. In this review, we discuss several techniques that employ fluorescence for early diagnosis and surgical guidance in oral squamous cell carcinoma and present future perspectives on the potential of fluorescence imaging in oral cancer in the near future.
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