期刊
BIOSENSORS & BIOELECTRONICS
卷 68, 期 -, 页码 516-520出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2015.01.028
关键词
Gold nanoparticles; Heteropyramids; Circular dichroism; Mercury ion
类别
资金
- National Technology Support Program of China [2012BAD28B01]
- International Technology Cooperation Program of Jiangsu Province, China [BZ2014034]
In this study, plasmonic heteropyramids (HPs) made from two different sized gold nanoparticles (Au NPs) and five ssDNA sequences and their application for ultrasensitive detection of mercury ion (Hg2+) were demonstrated. Four ssDNA sequences were used as building blocks to form a pyramidal DNA frame, which contains a T-rich probe DNA at one vertex and three sulfhydryl groups modified with 10 nm Au NPs at the other three vertices. Another T-rich DNA sequence was modified and attached to a 25nm Au NP. In the presence of Hg2+ ions, 25 nm Au NPs hybridized with pyramidal DNA frame to build the plasmonic HPs based on T-Hg2+-T interaction, which exhibits unprecedented circular dichroism (CD) signal in the visible region. Based on this mechanism, a simple, high sensitive and selective chiroplasmonic HPs-based probe was constructed and demonstrated for Hg2+ ions detection. Under optimized conditions, Hg2+ ions could be selectively detected in a concentration range from 1 to 500 pg mL(-1) with a limit of detection of 0.2 pg mL(-1), which is much lower than the strictest Hg2+ safety requirement of 1 ng mL(-1) in water. (C) 2015 Elsevier B.V. All rights reserved.
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