期刊
NEW BIOTECHNOLOGY
卷 54, 期 -, 页码 13-27出版社
ELSEVIER
DOI: 10.1016/j.nbt.2019.08.003
关键词
Antibiotics; Transformation; Biodegradation; Subsistence; B-lactams; Macrolides; Quinolones; Ionophore antibiotics
资金
- Portuguese Foundation for Science and Technology (FCT) [SFRH/BD/95814/2013, POCI-01-0145-FEDER006939, UID/EQU/00511/2013, NORTE-01-0145-FEDER-000005 -LEPABE-2-ECO-INNOVATION]
- Swiss National Science Foundation [160332]
- European Regional Development Fund (ERDF)
- Fundação para a Ciência e a Tecnologia [SFRH/BD/95814/2013] Funding Source: FCT
Antibiotic residues are widespread in the environment and their presence is known to contribute to the propagation of antibiotic resistance. Nevertheless, knowledge on processes involved in their degradation is scattered. This second part of a two part review aims at compiling knowledge on the (bio-) degradation of antibiotics, focusing on beta-lactams, macrolides, quinolones and ionophores, as well as some less common classes. Detailed metabolic and molecular aspects are discussed, as well as the role of antibiotic degraders in natural microbial communities. This exercise led to the conclusion that among the classes analyzed, the majority of antibiotics are prone to microbial cleavage or transformation.
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