期刊
NEUROSCIENCE RESEARCH
卷 156, 期 -, 页码 14-23出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neures.2020.02.010
关键词
GABA; KCC2; NKCC1; Cation-chloride cotransporter; Cl- homeostasis; Neurological diseases; Neurodevelopmental disorders; Oscillology
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan [15H05872]
- Grants-in-Aid for Scientific Research [15H05872] Funding Source: KAKEN
gamma-Aminobutyric acid (GABA) generally induces hyperpolarization and inhibition in the adult brain, but causes depolarization (and can be excitatory) in the immature brain. Depolarizing GABA actions are necessary for neurogenesis, differentiation, migration, and synaptogenesis. Additionally, the conversion of GABA responses from inhibition to excitation can be induced in adults by pathological conditions. Because GABAA receptors are Cl- channels, alternating GABA actions between hyperpolarization (Cl- influx) and depolarization (Cl- efflux) are induced by changes in the Cl- gradient, which is regulated by C- transporters. Thus, the dynamics of neural functions are modulated by active Cl- homeostasis (Cl- homeodynamics), alternating inhibition and excitation, and could underlie the modal shifts in cellular and network oscillations. Such a modal shift in GABA actions is required for normal development. Thus disturbances in this developmental GABA modal shift and/or the induction of excitatory GABA action in adult could underlie the pathogenesis of diverse neurological diseases (so-called network diseases). (C) 2020 Elsevier B.V. and Japan Neuroscience Society. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据