期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 107, 期 -, 页码 329-345出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2019.09.020
关键词
Fear conditioning; Fear extinction; Associative learning; Rodent; Human; Translation; Meta-research; Startle; FPS; SCR; Treezing; Heat-rate; Paradigm; Methods; Individual differences
资金
- German Research Foundation (DFG), Scientific Network grant [LO 1980/2-1]
- German Research Foundation of the Collaborative Research Center [INST 211/755, INST INST 211/633-2, TRR58]
- German Research Foundation of the Collaborative Research Center 1280 Extinction Learning
- Daimler and Benz foundation grant
Translational neuroscience bridges insights from specific mechanisms in rodents to complex functions in humans and is key to advance our general understanding of central nervous function. A prime example of translational research is the study of cross-species mechanisms that underlie responding to learned threats, by employing Pavlovian fear conditioning protocols in rodents and humans. Hitherto, evidence for (and critique of) these cross-species comparisons in fear conditioning research was based on theoretical viewpoints. Here, we provide a perspective to substantiate these theoretical concepts with empirical considerations of cross-species methodology. This meta-research perspective is expected to foster cross-species comparability and reproducibility to ultimately facilitate successful transfer of results from basic science into clinical applications.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据