期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 107, 期 -, 页码 525-539出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2019.09.040
关键词
Exercise; Depression; Mental health; Neuroplasticity; Inflammation; Hippocampus; Oxidative stress; Self-esteem; Self-efficacy; Social support; HPA; Stress; BDNF; Non-pharmacological
资金
- ESRC scholarship [ES/P000592/1]
- Mitacs Globalink Award
- Canada Research Chairs Program
- RTS scholarship
- Health Education England
- National Institute for Health Research HEE NIHR ICA Program Clinical Lectureship [ICA-CL-2017-03-001]
- Maudsley Charity
- National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care South London at King's College Hospital NHS Foundation Trust
Physical activity can treat and prevent depressive symptoms, but its antidepressant mechanisms are yet to be established. In this review, we comprehensively assess key biological and psychosocial mechanisms through which physical activity exerts antidepressant effects, with a particular focus on exercise. Exercise, a subset of physical activity, influences a range of biological and psychosocial processes also implicated in the pathophysiology of depression. We focus on the capacity for exercise to elicit changes in neuroplasticity, inflammation, oxidative stress, the endocrine system, self-esteem, social support and self-efficacy. We also discuss how a better understanding of these mechanisms can inform the way we design and implement exercise-based interventions to maximise their antidepressant effects on an individual basis. We conclude by presenting a conceptual framework of the key biological and psychosocial mechanisms underlying the relationship between physical activity and depressive symptoms, and the moderators and confounders that may influence it.
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