期刊
NEURON
卷 106, 期 2, 页码 316-+出版社
CELL PRESS
DOI: 10.1016/j.neuron.2020.01.034
关键词
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资金
- NSF NeuroNex Award [DBI-1707398]
- Burroughs Wellcome Foundation
- Gatsby Charitable Foundation
- Howard Hughes Medical Institute (HHMI)
- Simons Foundation
Cognitive capacities afford contingent associations between sensory information and behavioral responses. We studied this problem using an olfactory delayed match to sample task whereby a sample odor specifies the association between a subsequent test odor and rewarding action. Multi-neuron recordings revealed representations of the sample and test odors in olfactory sensory and association cortex, which were sufficient to identify the test odor as match or non-match. Yet, inactivation of a downstream premotor area (ALM), but not orbitofrontal cortex, confined to the epoch preceding the test odor led to gross impairment. Olfactory decisions that were not context-dependent were unim-paired. Therefore, ALM does not receive the outcome of a match/non-match decision from upstream areas. It receives contextual information-the identity of the sample-to establish the mapping be-tween test odor and action. A novel population of pyramidal neurons in ALM layer 2 may mediate this process.
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