期刊
NEUROIMAGE
卷 205, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2019.116240
关键词
Serotonin; PET; MRI; Clustering; Structure; mRNA
资金
- Independent Research Fund Denmark [DFF-4183-00627]
- Lundbeck foundation [R181-2014-3586, R231-2016-3236]
- Ontario Brain Institute
- CIHR Operating Grant [MOP 201403]
- NIH [R01 EB023281-01]
- Marie-Curie-NEUROMODEL
The human brain atlas of the serotonin (5-HT) system does not conform with commonly used parcellations of neocortex, since the spatial distribution of homogeneous 5-HT receptors and transporter is not aligned with such brain regions. This discrepancy indicates that a neocortical parcellation specific to the 5-HT system is needed. We first outline issues with an existing parcellation of the 5-HT system, and present an alternative parcellation derived from brain MR- and high-resolution PET images of five different 5-HT targets from 210 healthy controls. We then explore how well this new 5-HT parcellation can explain mRNA levels of all 5-HT genes. The parcellation derived here represents a characterization of the 5-HT system which is more stable and explains the underlying 5-HT molecular imaging data better than other atlases, and may hence be more sensitive to capture region-specific changes modulated by 5-HT.
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