期刊
NEUROCHEMICAL RESEARCH
卷 45, 期 6, 页码 1335-1343出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11064-020-03001-6
关键词
Dopamine transporter; Membrane trafficking; Striatum
资金
- NIDA NIH HHS [DA035224, F31 DA045446-A1, R01 DA015169, R01 DA035224] Funding Source: Medline
Dopamine (DA) is critical for motivation, reward, movement initiation, and learning. Mechanisms that control DA signaling have a profound impact on these important behaviors, and additionally play a role in DA-related neuropathologies. The presynaptic SLC6 DA transporter (DAT) limits extracellular DA levels by clearing released DA, and is potently inhibited by addictive and therapeutic psychostimulants. Decades of evidence support that the DAT is subject to acute regulation by a number of signaling pathways, and that endocytic trafficking strongly regulates DAT availability and function. DAT trafficking studies have been performed in a variety of model systems, including both in vitro and ex vivo preparations. In this review, we focus on the breadth of DAT trafficking studies, with specific attention to, and comparison of, how context may influence DAT's response to different stimuli. In particular, this overview highlights that stimulated DAT trafficking not only differs between in vitro and ex vivo environments, but also is influenced by both sex and anatomical subregions.
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